Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases
Yujie Fan, Jonathan D. Hoang, Chelsie Steele, Yochana Benchetrit, Sayan Dutta, Gerard Michael Coughlin, Nathan Appling, Xiaozhe Ding, Changfan Lin, Zhe Qu, Elisha D. Mackey, Viviana Gradinaru
The paper introduces a programmable self-assembling protein system to model intracellular protein aggregation in neurodegenerative diseases and reveals disease-specific aggregate-organelle interactions.
bioRxiv · Mar 6, 2025 · PreprintNeuroscience