Jonathan D. Hoang

Spinal nociceptive denervation impedes subsequent chronic autonomic remodeling after myocardial infarction in male swine

This study shows that spinal nociceptive denervation reduces autonomic remodeling and ventricular arrhythmias after myocardial infarction in male swine.

Structural basis of liver de-targeting and neuronal tropism of CNS-targeted AAV capsids

The paper solves cryo-EM structures of AAV capsids and their complexes with AAVR to design variants with reduced liver targeting and altered brain cell tropism.

AAVs Targeting Human Carbonic Anhydrase IV Enhance Gene Delivery to the Brain

This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.

The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases

The paper introduces a programmable self-assembling protein system to model intracellular protein aggregation in neurodegenerative diseases and reveals disease-specific aggregate-organelle interactions.