The conserved coordination of acyl-homoserine lactone and PqsE signaling defines the RhlR-dependent quorum-sensing network in Pseudomonas aeruginosa clinical isolates
Elizabeth G Knorr, Elizabeth A Key, Megan L. Schumacher, Leah M. Kemper, Caleb P. Mallery, Navjot Singh, Jon E. Paczkowski
This study shows that both C4HSL and PqsE are essential for RhlR-dependent gene expression in Pseudomonas aeruginosa clinical isolates, revealing a conserved regulatory module for virulence.
bioRxiv · May 21, 2026 · PreprintMicrobiology