Caleb P. Mallery

This study shows that both C4HSL and PqsE are essential for RhlR-dependent gene expression in Pseudomonas aeruginosa clinical isolates, revealing a conserved regulatory module for virulence.

The paper analyzes how medically important antimicrobials bind to the 30S ribosomal subunit of Borrelia burgdorferi using structural analogy and computational methods to predict binding free energy.

This study identifies key residues in RhlR that determine ligand specificity and shows how ligand-driven gene regulation affects phenazine gene expression in Pseudomonas aeruginosa.

This study identifies PTSP as a ligand that induces proteolytic degradation of SmcR, controlling quorum sensing state transitions in Vibrio species.

This study investigates the conservation and function of PqsE in Pseudomonas and Burkholderia, showing that PqsE in Pseudomonas enhances RhlR activity while Burkholderia orthologs do not.