Jon E. Paczkowski

This study shows that proteolytic feedback regulates quorum sensing in Pseudomonas aeruginosa by controlling RhlR stability, affecting virulence and biofilm formation.

This study shows that both C4HSL and PqsE are essential for RhlR-dependent gene expression in Pseudomonas aeruginosa clinical isolates, revealing a conserved regulatory module for virulence.

This study identifies PhoPQ as a regulator of quorum sensing in small colony variants of Pseudomonas aeruginosa, showing its role in virulence factor production and subpopulation adaptation.

This study identifies key residues in RhlR that determine ligand specificity and shows how ligand-driven gene regulation affects phenazine gene expression in Pseudomonas aeruginosa.

This study identifies PTSP as a ligand that induces proteolytic degradation of SmcR, controlling quorum sensing state transitions in Vibrio species.

This study investigates the conservation and function of PqsE in Pseudomonas and Burkholderia, showing that PqsE in Pseudomonas enhances RhlR activity while Burkholderia orthologs do not.

This paper shows that Enterococcus faecalis reduces Pseudomonas aeruginosa's production of quinolone signals and pyocyanin through ornithine, enabling mutualistic survival in co-culture.