Control of Inflammatory Response by Tissue Microenvironment
Zhongyang Wu, Scott D. Pope, Nasiha S. Ahmed, Diana L. Leung, Stephanie Hajjar, Qiuyu Yue, Diya M. Anand, Elizabeth B. Kopp, Daniel Okin, Weiyi Ma, Jonathan C. Kagan, Diana C. Hargreaves, Ruslan Medzhitov, Xu Zhou
This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.
bioRxiv · May 10, 2024 · PreprintImmunology