Xu Zhou

The paper identifies universal and tissue-specific transcriptional programs in human and mouse tissues using single-cell RNA sequencing and shows how they coordinate function across organs.

This study shows that redox balance, regulated by NOX1 and HIF1-IDH1 interactions, controls epithelial stem cell fate in the distal colon niche.

The paper identifies transcriptional regulators involved in pH-sensitive transcriptional condensates that modulate immune gene expression in macrophages under acidic conditions.

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

This study develops a degrader for Siglec-7 and -9 to reshape the tumor microenvironment and enhance T cell anti-tumor immunity in murine models.

This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.

This study identifies a cell-circuit framework for wound healing and fibrosis, revealing three fibrosis outcomes and parameters that control the transition from healing to fibrosis.