Author

Zhongyang Wu

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Xu ZhouiD· 3 shared Andrew Kwong· 1 shared Anoohya N. MuppiralaiD· 1 shared Bin BaoiD· 1 shared Chongzhi ZangiD· 1 shared Clara BaekiD· 1 shared Daniel KotlarziD· 1 shared Daniel Okin· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Xu ZhouORCID

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Author profile →

4 papers

Recent·Most cited

A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

Xi Chen, Krishnan Raghunathan, Bin Bao, Elsy M. Ngwa, Andrew Kwong, Zhongyang Wu, Stephen J. Babcock, Clara Baek, George Ye, Anoohya N. Muppirala, Qianni Peng, Michael L. Rutlin, Mantu Bhaumik, Daping Yang, Daniel Kotlarz, , Jay R. Thiagarajah

This study shows that redox balance, regulated by NOX1 and HIF1-IDH1 interactions, controls epithelial stem cell fate in the distal colon niche.

Nature Communications · Nov 28, 2025Peer-reviewedCell Biology

Transcriptional condensates at super-enhancers mediate pH-dependent transcriptional control in innate immunity

Shengyuan Wang, Zhongyang Wu, Zhe Zhong, Xu Zhou, Chongzhi Zang

The paper identifies transcriptional regulators involved in pH-sensitive transcriptional condensates that modulate immune gene expression in macrophages under acidic conditions.

bioRxiv · Oct 29, 2025 · PreprintImmunology

Control of Inflammatory Response by Tissue Microenvironment

Zhongyang Wu, Scott D. Pope, Nasiha S. Ahmed, Diana L. Leung, Stephanie Hajjar, Qiuyu Yue, Diya M. Anand, Elizabeth B. Kopp, Daniel Okin, Weiyi Ma, Jonathan C. Kagan, Diana C. Hargreaves, Ruslan Medzhitov, Xu Zhou

This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.

bioRxiv · May 10, 2024 · PreprintImmunology

L1 and B1 repeats blueprint the spatial organization of chromatin

J. Yuyang Lu, Lei Chang, Tong Li, Ting Wang, Yafei Yin, Ge Zhan, Ke Zhang, Michelle Percharde, Liang Wang, Qi Peng, Pixi Yan, Hui Zhang, Xue Han, Xianju Bi, Wen Shao, , Xiaohua Shen

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

bioRxiv · Oct 13, 2019 · PreprintGenomics