Jonathan C. Kagan

This study identifies NLRP11 as a primate-specific factor that enhances CASP4-mediated cLPS detection and non-canonical inflammasome activation in human macrophages.

This study identifies NINJ1 as a mediator of plasma membrane rupture in Mtb-infected macrophages, showing it operates independently of canonical cell death pathways and requires the ESX-1 secretion system.

This study identifies wall teichoic acid (WTA) as a key mediator of DNA release from Staphylococcus aureus during infection, influencing activation of innate immune receptors.

This study identifies the caspase-11 CARD as a bipartite lipid-binding module that recognizes both self and nonself lipids, enabling the design of an LPS-binding domain.

This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.