Mapping Alzheimer's neuropathology signatures to the whole brain transcriptome using machine learning data fusion
Anwesha Bhattacharya, Chloé Savignac, L. M. Hodgson, Jack Stanley, Guy Wolf, Smita Krishnaswamy, David A. A Bennett, Elizabeth Binder, Danilo Bzdok
Cell type-specific logistic regression estimators trained on 427 ROSMAP prefrontal donors project Braak- and β-amyloid-like transcriptomic signatures onto the 108-region Siletti atlas, flagging brainstem, hypothalamic and rostral hippocampal regions.
bioRxiv · Aug 26, 2026 · PreprintNeuroscience✦ In-depth digest