This study shows that deep brain stimulation remodels white matter and alters brain-wide functional connectivity in macaques, contributing to its therapeutic effects.

Nature Neuroscience · Jun 1, 2026Peer-reviewedNeuroscience

Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex

Blair R. K. Shevlin, Qi Xiu Fu, Seth R. Batten, Brian Harris Kopell, Arianna Neal Davis, Matthew Heflin, Stephen Heisig, Christopher J. Rozell, Ayaka Kato, Kaustubh R. Kulkarni, Ki Sueng Choi, Ha Neul Song, Shannon K. O’Neill, Tanya Nauvel, Isha Trivedi, , Xiaosi Gu

This paper shows that dopamine and serotonin changes during deep brain stimulation predict symptom relief in treatment-resistant depression.

Biological Psychiatry · Apr 25, 2026Peer-reviewedNeuroscience

Longitudinal Changes in Cortical Response Dynamics with Deep Brain Stimulation to the Subcallosal Cingulate for Treatment-Resistant Depression

Aashna Desai, Tine Van Bogaert, Ki Sueng Choi, Ha Neul Song, Jungho Cha, Sankaraleengam Alagapan, Elisa Xu, Jacob Francis Dahill-Fuchel, Ashan Veerakumar, Brian Harris Kopell, Martijn Figee, Patricio Riva‐Posse, Christopher J. Rozell, Helen S. Mayberg, Allison C. Waters

This study tracks changes in cortical response dynamics during SCC-DBS for treatment-resistant depression, finding reduced latency and increased magnitude of stimulation-evoked potentials over time.

bioRxiv · Nov 26, 2025 · PreprintNeuroscience

Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression

Boadie Waid Dunlop, Jungho Cha, Helen S. Mayberg, Ki Sueng Choi, W. Edward Craighead, Siamak MahmoudianDehkordi, Sudeepa Bhattacharyya, Augustus John Rush, Rima F Kaddurah-Daouk

The paper examines the association between bile acid levels and functional connectivity of the executive control and default mode networks in patients with major depression.

bioRxiv · Dec 20, 2024 · PreprintNeuroscience

Neural Interoceptive Processing is Modulated by Deep Brain Stimulation for Treatment Resistant Depression

Elisa Xu, Samantha Pitts, Jacob Francis Dahill-Fuchel, Sara Scherrer, Tanya Nauvel, Jacqueline A. Overton, Patricio Riva‐Posse, Andrea L. Crowell, Martijn Figee, Sankaraleengam Alagapan, Christopher J. Rozell, Ki Sueng Choi, Helen S. Mayberg, Allison C. Waters

This study examines how deep brain stimulation affects interoceptive processing in treatment-resistant depression patients using EEG and HEP measurements.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging · Nov 30, 2024Peer-reviewedNeuroscience

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry L. Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga Rama Krishnan, Augustus John Rush, Boadie Waid Dunlop, Rima F Kaddurah-Daouk, Brenda W.J.H. Penninx, Elizabeth Binder, , Piero Rinaldo

The paper links indoxyl sulfate, a gut microbiome-derived metabolite, to anxiety symptoms and specific brain connectivity patterns in patients with depression.

Scientific Reports · Oct 25, 2021Peer-reviewedNeuroscience

Alterations in Acylcarnitines, Amines, and Lipids Inform about Mechanism of Action of Citalopram/Escitalopram in Major Depression

Siamak MahmoudianDehkordi, Ahmed T. Ahmed, Sudeepa Bhattacharyya, Xianlin Han, Rebecca Baillie, Matthias Arnold, Michelle K. Skime, Lisa St. John‐Williams, Martin Arthur Moseley, J. Will Thompson, Gregory Louie, Patricio Riva‐Posse, W. Edward Craighead, William Maffitt McDonald, Ranga Rama Krishnan, , Rick Jansen

The paper uses targeted metabolomics to analyze changes in acylcarnitines, amines, and lipids in response to citalopram/escitalopram treatment in MDD patients, identifying metabolic correlates of treatment response.

Translational Psychiatry · Mar 2, 2021Peer-reviewedNeuroscience