Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry L. Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga Rama Krishnan, Augustus John Rush, Boadie Waid Dunlop, Rima F Kaddurah-Daouk, Brenda W.J.H. Penninx, Elizabeth Binder, , Piero Rinaldo
The paper links indoxyl sulfate, a gut microbiome-derived metabolite, to anxiety symptoms and specific brain connectivity patterns in patients with depression.
Scientific Reports · Oct 25, 2021Peer-reviewedNeuroscience