Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent Mechanism
Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh Daniel Plant
This study shows hypoxia worsens Kir2.1 channel dysfunction in an Andersen-Tawil Syndrome variant through SUMOylation, and TAK-981 reverses this effect.
bioRxiv · Apr 25, 2025 · PreprintPhysiology