Neurodegeneration risk variants promote lysosomal TMEM106B fibrilaccumulation
John Michael Replogle, Jordan D. Marks, Martin G. Fernandez, Hebao Yuan, Dahyun Yu, Elizabeth Winters, Vidhya Maheswari Jawahar, Rishi Deshmukh, Renaldo Sutanto, Isabelle Kowal, Ashley M. Frankenfield, Rachel Shi, Yari Carlomagno, Karen R. Jansen‐West, Tiffany W. Todd, , Michael Emmerson Ward
The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.
bioRxiv · Mar 28, 2026 · PreprintCell Biology