Author
National Institutes of HealthORCID 0000-0003-4425-3678Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
John Michael Replogle, Jordan D. Marks, Martin G. Fernandez…·Michael Emmerson Ward
The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.
Femke M. Feringa, Sascha Koppes-den Hertog, Lian Y. Wang…·Rik van der Kant
The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.
Veronica H. Ryan, Sydney Lawton, Joel F. Reyes…·Michael Emmerson Ward
The paper identifies BORC as a modifier of TDP-43 protein levels in neurons, showing lysosome transport is required for TDP-43 turnover.
Sahba Seddighi, Yue Andy Qi, Anna‐Leigh Brown…·Michael Emmerson Ward
The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.