Ashley M. Frankenfield

The paper develops a platform to measure protein turnover in human iPSC-derived neurons, revealing conserved and subtype-specific proteome dynamics.

The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.

The paper identifies BORC as a modifier of TDP-43 protein levels in neurons, showing lysosome transport is required for TDP-43 turnover.

This study uses proteomic techniques to show that PGRN deficiency impairs lysosomal function and proteostasis in neurons by altering pH, enzyme levels, and protein turnover.

This study develops universal protein contaminant libraries for DDA and DIA proteomics to reduce false discoveries and improve protein identification without affecting quantification accuracy.

The paper develops and evaluates a proximity labeling method to study the endolysosomal proteome in human neurons, showing improved data normalization and complementary coverage compared to overexpression approaches.