Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis
Romie Angelo G Azur, Daniel Feliciano, Isabel Espinosa-Medina, Raghabendra Adhikari, Joaquín Lilao‐Garzón, Ella Jensen, Ching-Po Yang, Tzumin Lee
This study shows Imp1 regulates temporal fate transitions in radial glia during cortical development, affecting neuronal identity and spatial organization through dosage and stage-dependent mechanisms.
bioRxiv · Nov 18, 2025 · PreprintDevelopmental Biology