Joaquín Lilao‐Garzón

Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis

This study shows Imp1 regulates temporal fate transitions in radial glia during cortical development, affecting neuronal identity and spatial organization through dosage and stage-dependent mechanisms.

Regulation of mouse blastocyst primitive endoderm differentiation by p38-mitogen-activated-kinases (p38-MAPKs) is inner-cell-mass (ICM) autonomous and unrelated to cavity expansion defects in ICM specification.

The paper investigates whether p38-MAPK inhibition affects primitive endoderm differentiation in mouse blastocysts through ICM autonomous mechanisms or cavity expansion defects.

Wnt/β-catenin signalling assists cell fate decision making in the early mouse embryo

This study shows Wnt/β-catenin signalling promotes primitive endoderm (PrE) fate in mouse preimplantation embryos by working with FGF/ERK and regulating GATA6/GATA4 stability.

The salt-and-pepper pattern in mouse blastocysts is compatible with signalling beyond the nearest neighbours.

The paper analyzes the salt-and-pepper pattern in mouse blastocysts and shows it results from long-range signaling, not just local interactions.

Maternal age, obesity and hyperglycaemia are associated with a delay in preimplantation development in a mouse model of type 2 diabetes

This study shows that maternal age and high fat diet reduce preimplantation embryo development in mice, with older age having a greater impact than diet.

Exploring the link between Parkinson's disease and Diabetes Mellitus in Drosophila

This study investigates the link between Parkinson's disease and diabetes mellitus using Drosophila models, finding that T2DM may increase PD risk and that metformin could prevent PD onset in T2DM models.

Three-dimensional cell neighbourhood impacts differentiation in the inner mass cells of the mouse blastocyst

The paper investigates how three-dimensional cell neighbourhoods in mouse blastocysts influence cell fate decisions by analyzing NANOG and GATA6 expression patterns.