Glucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death
Luke R. Vass, Ella Weber Smith, Jayda Marie Cavanaugh, Summer Lee Johnson, Ariana Sabzevari, Pedro Costa‐Pinheiro, Jeremy J.P. Shaw, Thomas P. Loughran, Todd E. Fox
This study shows that glucosylceramide synthase inhibition protects cells from ceramide nanoliposome-induced death by preventing glycosphingolipid accumulation.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology