Author

Todd E. Fox

University of VirginiaORCID 0000-0001-5170-3951Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Thomas P. LoughraniD· 4 shared David J. FeithiD· 3 shared Jeremy J.P. ShawiD· 3 shared Arati K. SharmaiD· 2 shared Ariana SabzevariiD· 2 shared B. Bishal PaudeliD· 2 shared David F. ClaxtoniD· 2 shared Francine E. Garrett-BakelmaniD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

Thomas P. LoughranORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 22, 2026

Glucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death

Luke R. Vass, Ella Weber Smith, Jayda Marie Cavanaugh…·Todd E. Fox

This study shows that glucosylceramide synthase inhibition protects cells from ceramide nanoliposome-induced death by preventing glycosphingolipid accumulation.

DOI 10.64898/2026.09.21.753214

humanexperimental assay

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Cancer BiologyBloodPeer-reviewedSep 2, 2025

PRECLINICAL DEVELOPMENT OF A ROMIDEPSIN NANOPARTICLE DEMONSTRATES SUPERIOR TOLERABILITY AND EFFICACY IN MODELS OF HUMAN T-CELL LYMPHOMA AND LARGE GRANULAR LYMPHOCYTE LEUKEMIA

Ipsita Pal, Anuradha Illendula, Andrea Joyner…·Owen A. O’Connor

6 citations

mouseexperimental assay

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Cancer BiologybioRxivPreprintJun 6, 2025

Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response

Johnson Ung, Su‐Fern Tan, Jeremy J.P. Shaw…·Thomas P. Loughran

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

DOI 10.1101/2025.06.06.657881

humanbulk RNA-seq

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Systems BiologyBlood AdvancesPeer-reviewedJan 3, 2024

Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes

B. Bishal Paudel, Su‐Fern Tan, Todd E. Fox…·Thomas P. Loughran

This study identifies two sphingolipidomic subtypes in AML, with one subtype associated with poor clinical outcomes and high-risk features.

10 citations

humanbulk RNA-seq

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