Author

Jeremy J.P. Shaw

St. Jude Children's Research HospitalORCID 0000-0002-7458-215XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Thomas P. LoughraniD· 3 shared Todd E. FoxiD· 3 shared Arati K. SharmaiD· 2 shared B. Bishal PaudeliD· 2 shared David F. ClaxtoniD· 2 shared David J. FeithiD· 2 shared Francine E. Garrett-BakelmaniD· 2 shared Johnson UngiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Thomas P. LoughranORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 22, 2026

Glucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death

Luke R. Vass, Ella Weber Smith, Jayda Marie Cavanaugh…·Todd E. Fox

This study shows that glucosylceramide synthase inhibition protects cells from ceramide nanoliposome-induced death by preventing glycosphingolipid accumulation.

DOI 10.64898/2026.09.21.753214

humanexperimental assay

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Cancer BiologybioRxivPreprintJun 6, 2025

Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response

Johnson Ung, Su‐Fern Tan, Jeremy J.P. Shaw…·Thomas P. Loughran

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

DOI 10.1101/2025.06.06.657881

humanbulk RNA-seq

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Systems BiologyBlood AdvancesPeer-reviewedJan 3, 2024

Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes

B. Bishal Paudel, Su‐Fern Tan, Todd E. Fox…·Thomas P. Loughran

This study identifies two sphingolipidomic subtypes in AML, with one subtype associated with poor clinical outcomes and high-risk features.

10 citations

humanbulk RNA-seq

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