Pedro Costa‐Pinheiro

Glucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death

This study shows that glucosylceramide synthase inhibition protects cells from ceramide nanoliposome-induced death by preventing glycosphingolipid accumulation.

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.