Discovery of Covalent Wild-Type Isocitrate Dehydrogenase 1 (IDH1) Inhibitors Targeting Cys269
C. C. Brown, Elliot O Harmer, Ariba Azam, Charlie Sharp, Sam Horrell, James A. Bull, Alan Armstrong, David J. Mann
This study develops covalent inhibitors targeting wild-type IDH1 by exploiting a unique hydrogen bonding network, achieving high potency and selectivity.
bioRxiv · Sep 25, 2026 · PreprintCancer Biology