Sam Horrell

This study develops covalent inhibitors targeting wild-type IDH1 by exploiting a unique hydrogen bonding network, achieving high potency and selectivity.

This paper uses photocaged molecular oxygen to trigger oxygen binding in myoglobin crystals and captures structural changes using time-resolved serial X-ray crystallography.

The paper describes the photoactivation mechanism of the B12 photoreceptor CarH using structural and spectroscopic methods, revealing unique intermediates that drive tetramer dissociation.

The paper demonstrates proof of concept for combined droplet on demand serial crystallography and XES experiments at a synchrotron beamline.

This study identifies a double crosslink between lysine and heme in Methylococcus capsulatus cytochrome P460 using structural biology and QM/MM simulations.

xia2.multiplex merges multi-crystal data sets in macromolecular crystallography to improve data quality and facilitate analysis.

The paper describes the rapid structural determination of SARS-CoV-2 proteins during the pandemic and the efforts to evaluate and improve these structures for drug and vaccine development.