Author

Alan Armstrong

Imperial College LondonORCID 0000-0002-3692-3099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

David J. ManniD· 2 shared Adam ThomasiD· 1 shared Alistair N. HumeiD· 1 shared Ariba Azam· 1 shared C. C. BrowniD· 1 shared Charlie Sharp· 1 shared Deborah A. Briggs· 1 shared Delia Brustur· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

David J. MannORCID

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2 papers

Recent·Most cited

Discovery of Covalent Wild-Type Isocitrate Dehydrogenase 1 (IDH1) Inhibitors Targeting Cys269

C. C. Brown, Elliot O Harmer, Ariba Azam, Charlie Sharp, Sam Horrell, James A. Bull, Alan Armstrong, David J. Mann

This study develops covalent inhibitors targeting wild-type IDH1 by exploiting a unique hydrogen bonding network, achieving high potency and selectivity.

bioRxiv · Sep 25, 2026 · PreprintCancer Biology

Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction

Elena De Vita, Adam Thomas, Delia Brustur, Montse Tersa, Rita Petracca, Shradda Vadodaria, Deborah A. Briggs, Jack W. Houghton, Thomas Lanyon‐Hogg, Gregory B. Craven, Rhodri M. L. Morgan, Alan Armstrong, David J. Mann, Katharine M. Lodge, Alistair N. Hume, , Edward W. Tate

This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.

Journal of the American Chemical Society · Aug 3, 2026Peer-reviewedBiochemistry