AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block
Jianan Wang, Evelien E. Birza, Veronique M.F. Meijborg, Arie O. Verkerk, Aina Cervera-Barea, Timo Jonker, Ruud N. Visser, Rinske Sparrius, Mischa Klerk, Arnie Boender, Yuting Yang, Emiel J.M. Kramer, Ganghyun Kwak, Kyungho Park, Larry C. Park, , Gerard J.J. Boink
This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.
bioRxiv · Jul 31, 2025 · PreprintPhysiology