Gerard J.J. Boink

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.

This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.

This study maps the transcriptional changes during human pacemaker cell differentiation using single-cell RNA sequencing and identifies roles for WNT and TGFβ signaling in subtype specification.