Author

Mischa Klerk

Amsterdam University Medical CentersORCID 0000-0002-3725-9943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Arnie BoenderiD· 3 shared Gerard J.J. BoinkiD· 3 shared Vincent M. ChristoffelsiD· 3 shared Arie O. VerkerkiD· 2 shared Christian ThirioniD· 2 shared Hanno L. TaniD· 2 shared Jianan WangiD· 2 shared Klaus NeefiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

Arnie BoenderORCID

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3 papers

Recent·Most cited

PhysiologyJournal of Clinical InvestigationPeer-reviewedJun 11, 2026

Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2

Jianan Wang, Mathilde R. Rivaud, Mischa Klerk…·Gerard J.J. Boink

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

1 citation

mouserat

Developmental BiologybioRxivPreprintApr 15, 2026

TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation in vivo

Alexandra E. Giovou, Otto J. Mulleners, Rocco Caliandro…·Vincent M. Christoffels

This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.

DOI 10.64898/2026.04.13.718086

mousebulk RNA-seq

PhysiologybioRxivPreprintJul 31, 2025

AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block

Jianan Wang, Evelien E. Birza, Veronique M.F. Meijborg…·Gerard J.J. Boink

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.

DOI 10.1101/2025.07.31.666254

ratplant (other)