Author

Hanno L. Tan

Amsterdam University Medical CentersORCID 0000-0002-7905-5818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:rat· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Vincent M. ChristoffelsiD· 3 shared Arie O. VerkerkiD· 2 shared Arnie BoenderiD· 2 shared Arthur A.M. WildeiD· 2 shared Christian ThirioniD· 2 shared Connie R. BezzinaiD· 2 shared Gerard J.J. BoinkiD· 2 shared Jianan WangiD· 2 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersPhysiology

Vincent M. ChristoffelsORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJul 10, 2026

Whole-genome sequencing implicates rare, low-frequency and structural non-coding variation at the SCN5A locus in Brugada syndrome

Alex Lipov, Manon Baudic, Pierre Lindenbaum…·Connie R. Bezzina

This study identifies rare and low-frequency non-coding variants at the SCN5A locus associated with Brugada syndrome using whole-genome sequencing and functional assays.

DOI 10.64898/2026.07.07.26356386

humanwhole-genome sequencing

PhysiologyJournal of Clinical InvestigationPeer-reviewedJun 11, 2026

Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2

Jianan Wang, Mathilde R. Rivaud, Mischa Klerk…·Gerard J.J. Boink

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

1 citation

mouserat

PhysiologybioRxivPreprintJul 31, 2025

AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block

Jianan Wang, Evelien E. Birza, Veronique M.F. Meijborg…·Gerard J.J. Boink

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.

DOI 10.1101/2025.07.31.666254

ratplant (other)

GeneticsEuropean Heart JournalPeer-reviewedJul 20, 2018

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

Foram N. Ashar, Rebecca N. Mitchell, Christine M. Albert…·Nona Sotoodehnia

This study evaluates the genetic architecture of sudden cardiac arrest through GWAS and Mendelian randomization, finding genetic correlations with CAD, height, BMI, and electrical instability traits.

86 citations

humanGWAS summary statistics