High extracellular osmolarity promotes yeast thermotolerance through osmotic modulation and glycerol-dependent adaptation.
Saki Oyama, Kosuke Shiraishi, Satoshi Okada, Fumiyoshi Abe, Anna Ahara, 伊東 玲奈, Kokona Kosuga, Emiko Kusumoto, Tetsuo Tokiwano, Hiroya Yurimoto, Takashi Ito, Nobushige Nakazawa, Yuki Yoshikawa
This study shows that high extracellular osmolarity improves yeast thermotolerance by modulating osmotic balance and enhancing glycerol accumulation under heat stress.
bioRxiv · Apr 23, 2026 · PreprintMicrobiology