Declining autophagy drives age-related axonal decay through microtubule alterations
Kriti Gupta, Haifa Alhadyian, Ceryce Collie, Emilia Gregory, Amaya Malmalabaduge, Natalia Sánchez‐Soriano
This study shows that declining autophagy in aged neurons leads to microtubule alterations, causing axonal and synaptic decay, and that enhancing autophagy can reverse these effects.
bioRxiv · Jun 2, 2026 · PreprintCell Biology