Eukaryotic Initiation Factor 5B (eIF5B)-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology
Pavan Lakshmi Narasimha, Jinay Patel, Ayan Chanda, Veda Hegde, Beruwalage Hirushika Fernando, Hannah Stephenson, Rebecca Mubaya, Aadarsh Shrestha, Steven C. Nakoneshny, Bo Young Ahn, Thomas Wayne Matthews, Shamir P. Chandarana, Robert D. Hart, Joseph Clyde Dort, Martin D. Hyrcza, , Nehal Thakor
This study shows that eIF5B is crucial for OSCC cell survival by enabling non-canonical translation of pro-survival mRNAs, and its inhibition reduces tumor growth and sensitizes cells to apoptosis.
bioRxiv · Feb 2, 2026 · PreprintCancer Biology