Author

Thomas Wayne Matthews

University of CalgaryORCID 0000-0002-7596-6470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ayan ChandaiD· 2 shared Martin D. HyrczaiD· 2 shared Pinaki BoseiD· 2 shared Robert D. Hart· 2 shared Shamir P. ChandaranaiD· 2 shared Steven C. NakoneshnyiD· 2 shared Aadarsh Shrestha· 1 shared Angela M. Y. ChaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Ayan ChandaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

PIAS1 loss and INHBA gain define a TGFβ-driven EMT state in OSCC progression

Ayan Chanda, Parisa Ghahremanifard, J. An, Rohit Arora, Anusi Sarkar, Angela M. Y. Chan, Doha Itani, Steven C. Nakoneshny, Thomas Wayne Matthews, Shamir P. Chandarana, Robert D. Hart, Joseph C. Dort, Martin D. Hyrcza, Shirin Bonni, Pinaki Bose

This study identifies PIAS1 loss and INHBA gain as drivers of TGFβ-induced EMT in OSCC, linking them to poor prognosis and therapeutic resistance.

bioRxiv · Sep 22, 2026 · PreprintCancer Biology

Eukaryotic Initiation Factor 5B (eIF5B)-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology

Pavan Lakshmi Narasimha, Jinay Patel, Ayan Chanda, Veda Hegde, Beruwalage Hirushika Fernando, Hannah Stephenson, Rebecca Mubaya, Aadarsh Shrestha, Steven C. Nakoneshny, Bo Young Ahn, Thomas Wayne Matthews, Shamir P. Chandarana, Robert D. Hart, Joseph Clyde Dort, Martin D. Hyrcza, , Nehal Thakor

This study shows that eIF5B is crucial for OSCC cell survival by enabling non-canonical translation of pro-survival mRNAs, and its inhibition reduces tumor growth and sensitizes cells to apoptosis.

bioRxiv · Feb 2, 2026 · PreprintCancer Biology