Author

Veda Hegde

University of LethbridgeORCID 0000-0001-9136-2709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1

Frequent Co-Authors

Nehal ThakoriD· 2 shared Pavan Lakshmi NarasimhaiD· 2 shared Rebecca Mubaya· 2 shared Aadarsh Shrestha· 1 shared Ayan ChandaiD· 1 shared Beruwalage Hirushika Fernando· 1 shared Bo Young AhniD· 1 shared Divya K. Sharma· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Nehal ThakorORCID

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2 papers

Recent·Most cited

Eukaryotic initiation factor 3F (eIF3F) regulates the IRES-mediated translation of Bcl-xL via its interaction with programmed cell death 4 (PDCD4) protein

Veda Hegde, Divya K. Sharma, Harshil Patel, Pavan Lakshmi Narasimha, Jason Luddu, Rebecca Mubaya, Martin Holčı́k, Nehal Thakor

This paper shows that eIF3F and PDCD4 interact to regulate IRES-mediated translation of Bcl-xL mRNA, with implications for glioblastoma pathophysiology.

International Journal of Molecular Sciences · Apr 29, 2026Peer-reviewedMolecular Biology

Eukaryotic Initiation Factor 5B (eIF5B)-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology

Pavan Lakshmi Narasimha, Jinay Patel, Ayan Chanda, Veda Hegde, Beruwalage Hirushika Fernando, Hannah Stephenson, Rebecca Mubaya, Aadarsh Shrestha, Steven C. Nakoneshny, Bo Young Ahn, Thomas Wayne Matthews, Shamir P. Chandarana, Robert D. Hart, Joseph Clyde Dort, Martin D. Hyrcza, , Nehal Thakor

This study shows that eIF5B is crucial for OSCC cell survival by enabling non-canonical translation of pro-survival mRNAs, and its inhibition reduces tumor growth and sensitizes cells to apoptosis.

bioRxiv · Feb 2, 2026 · PreprintCancer Biology