Author

Martin D. Hyrcza

University of CalgaryORCID 0000-0002-9633-3293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Ayan ChandaiD· 2 shared Pinaki BoseiD· 2 shared Robert D. Hart· 2 shared Shamir P. ChandaranaiD· 2 shared Steven C. NakoneshnyiD· 2 shared Thomas Wayne MatthewsiD· 2 shared Aadarsh Shrestha· 1 shared Alastair DroopiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Ayan ChandaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PIAS1 loss and INHBA gain define a TGFβ-driven EMT state in OSCC progression

Ayan Chanda, Parisa Ghahremanifard, J. An, Rohit Arora, Anusi Sarkar, Angela M. Y. Chan, Doha Itani, Steven C. Nakoneshny, Thomas Wayne Matthews, Shamir P. Chandarana, Robert D. Hart, Joseph C. Dort, Martin D. Hyrcza, Shirin Bonni, Pinaki Bose

This study identifies PIAS1 loss and INHBA gain as drivers of TGFβ-induced EMT in OSCC, linking them to poor prognosis and therapeutic resistance.

bioRxiv · Sep 22, 2026 · PreprintCancer Biology

Eukaryotic Initiation Factor 5B (eIF5B)-Driven Translational Control Impacts Oral Squamous Cell Carcinoma Pathophysiology

Pavan Lakshmi Narasimha, Jinay Patel, Ayan Chanda, Veda Hegde, Beruwalage Hirushika Fernando, Hannah Stephenson, Rebecca Mubaya, Aadarsh Shrestha, Steven C. Nakoneshny, Bo Young Ahn, Thomas Wayne Matthews, Shamir P. Chandarana, Robert D. Hart, Joseph Clyde Dort, Martin D. Hyrcza, , Nehal Thakor

This study shows that eIF5B is crucial for OSCC cell survival by enabling non-canonical translation of pro-survival mRNAs, and its inhibition reduces tumor growth and sensitizes cells to apoptosis.

bioRxiv · Feb 2, 2026 · PreprintCancer Biology

Activation of Wnt/β-catenin signalling by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary gland basal cell adenoma

Kim Wong, Justin A. Bishop, Ilan Weinreb, Marialetizia Motta, Martin Del Castillo Velasco‐Herrera, Emanuele Bellacchio, Ingrid Ferreira, Louise van der Weyden, Jacqueline Marcia Boccacino, Antonella Lauri, Giovannina Rotundo, Andrea Ciolfi, Saamin Cheema, Rebeca Olvera-León, Victoria Offord, , David J. Adams

Exome and transcriptome sequencing of salivary basal cell adenomas reveals a recurrent FBXW11 p.F517S mutation, exclusive with CTNNB1 p.I35T, together accounting for 94% of cases.

Nature Communications · May 19, 2025Peer-reviewedCancer Biology✦ In-depth digest