Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis.
Changfu Yao, Milena Espinola, Xue Liu, Y. Wang, Marilia Sanches Santos Rizzo Zuttion, Virinchi N. S. Kuchibhotla, Xiao Hui Zhang, Larissa G. P. Langhi Prata, Silvia Cho, Zackery Ortega, Emily Braghramian, Kimberly Merene, Susan E. Jackman, Antonina Caudill, Fatima Contreras, , Tanyalak Parimon
This study shows that syndecan-1 promotes AT2 cell senescence in lung fibrosis, contributing to fibrotic remodeling and suggesting it as a therapeutic target.
bioRxiv · Apr 1, 2026 · PreprintCell Biology