Barry R. Stripp

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis.

This study shows that syndecan-1 promotes AT2 cell senescence in lung fibrosis, contributing to fibrotic remodeling and suggesting it as a therapeutic target.

Phosphatidylcholine Metabolism Controls Alveolar Progenitor Renewal and Pulmonary Fibrosis

This study identifies LPCAT1 as a critical regulator of AT2 cell renewal and lipid metabolism in IPF, showing that reactivating LPCAT1 can mitigate lung fibrosis.

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice

This study identifies NAMPT as a key regulator of alveolar progenitor cell function in IPF, showing that its activation restores homeostasis and reverses fibrosis in mice.

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

This paper reports the derivation of airway basal stem cells from human iPSCs, demonstrating their ability to self-renew and differentiate into airway epithelial cell types, and model lung diseases.

STK11 is required for the normal program of ciliated cell differentiation in airways

This study shows STK11 is essential for ciliated cell differentiation by regulating MARK3 and ERK1/2 signaling in airway progenitors.

The maternal-fetal interface of successful pregnancies and impact of fetal sex using single cell sequencing

The paper uses single-cell RNA sequencing to analyze maternal-fetal interface cell types and identifies sex-specific differences in immune cell function and regulatory pathways.