Author

Emily DeBitetto

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:spatial transcriptomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Agnel J. SfeiriD· 2 shared Craig B. ThompsoniD· 2 shared Ed ReznikiD· 2 shared Max LandiD· 2 shared Rahul Saha· 2 shared Roshan SharmaiD· 2 shared Ruobing CuiiD· 2 shared Alexander van OudenaardeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenomics

Agnel J. SfeirORCID

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2 papers

Recent·Most cited

Random mtDNA mutagenesis maps genotype-phenotype associations across metabolic contexts and lineages

Amir Giladi, Ron Baik, Chih-Yao Chung, Minsoo Kim, Josephine Adams, Rahul Saha, Max Land, Ruobing Cui, Emily DeBitetto, Megan E. Kelley, Craig B. Thompson, Ed Reznik, Roshan Sharma, Ronan Challinge, R. Stefan Isaac, , Agnel J. Sfeir

The paper introduces mtDIVE, a random mtDNA mutagenesis platform, to study genotype-phenotype associations in metabolic contexts and lineages, revealing lineage-specific effects and mutation-specific impacts.

bioRxiv · Oct 9, 2026 · PreprintGenomics

Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria

Yi Fu, Max Land, Tamar Kavlashvili, Ruobing Cui, Min‐Soo Kim, Emily DeBitetto, Toby Lieber, Keun Woo Ryu, Elim Choi, Ignas Masilionis, Rahul Saha, Meril T. Takizawa, Daphne Baker, Marco Tigano, Caleb A. Lareau, , Agnel J. Sfeir

This paper develops a method to engineer specific mtDNA deletions in human cells using end-joining machinery and targeted endonucleases, revealing a 75% heteroplasmy threshold for mitochondrial dysfunction.

Cell · May 1, 2025Peer-reviewedMolecular Biology