Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis
Sayed Obaidullah Aseem, J Wang, Ahmed M. Younis, Diana Nakib, Grayson W. Way, Christiane Carter, Derrick Zhao, Yunling Tai, Xuan Wang, Emily Gurley, Sonya A. MacParland, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Robert C. Huebert, Saul J. Karpen, , Huiping Zhou
This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.
bioRxiv · May 22, 2026 · PreprintPhysiology