Author

Robert C. Huebert

Mayo ClinicORCID 0000-0002-9812-7573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Arun Jayant SanyaliD· 2 shared Derrick Zhao· 2 shared Grayson W. WayiD· 2 shared Huiping ZhouiD· 2 shared Nidhi Jalan‐SakrikariD· 2 shared Phillip B. HylemoniD· 2 shared Sayed Obaidullah AseemiD· 2 shared Yunling Tai· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Arun Jayant SanyalORCID

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2 papers

Recent·Most cited

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis

Sayed Obaidullah Aseem, J Wang, Ahmed M. Younis, Diana Nakib, Grayson W. Way, Christiane Carter, Derrick Zhao, Yunling Tai, Xuan Wang, Emily Gurley, Sonya A. MacParland, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Robert C. Huebert, Saul J. Karpen, , Huiping Zhou

This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.

bioRxiv · May 22, 2026 · PreprintPhysiology

Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes

Sayed Obaidullah Aseem, Jing Wang, Maleeha F. Kalaiger, Grayson W. Way, Derrick Zhao, Yunling Tai, Emily C. Gurley, Jing Zeng, Xuan Wang, L. Ashley Cowart, Robert C. Huebert, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Arun Jayant Sanyal, Huiping Zhou

This study shows Aramchol reduces fibrosis in mouse models of biliary disease by inhibiting TGFβ-induced inflammation and fibrotic markers in cholangiocytes.

Hepatology Communications · Jul 28, 2025Peer-reviewedCell Biology