Author

Derrick Zhao

Virginia Commonwealth University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Huiping ZhouiD· 4 shared Yunling Tai· 3 shared Arun Jayant SanyaliD· 2 shared Grayson W. WayiD· 2 shared Nidhi Jalan‐SakrikariD· 2 shared Phillip B. HylemoniD· 2 shared Robert C. HuebertiD· 2 shared Sayed Obaidullah AseemiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

Huiping ZhouORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis

Sayed Obaidullah Aseem, J Wang, Ahmed M. Younis, Diana Nakib, Grayson W. Way, Christiane Carter, Derrick Zhao, Yunling Tai, Xuan Wang, Emily Gurley, Sonya A. MacParland, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Robert C. Huebert, Saul J. Karpen, , Huiping Zhou

This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.

bioRxiv · May 22, 2026 · PreprintPhysiology

Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes

Sayed Obaidullah Aseem, Jing Wang, Maleeha F. Kalaiger, Grayson W. Way, Derrick Zhao, Yunling Tai, Emily C. Gurley, Jing Zeng, Xuan Wang, L. Ashley Cowart, Robert C. Huebert, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Arun Jayant Sanyal, Huiping Zhou

This study shows Aramchol reduces fibrosis in mouse models of biliary disease by inhibiting TGFβ-induced inflammation and fibrotic markers in cholangiocytes.

Hepatology Communications · Jul 28, 2025Peer-reviewedCell Biology

Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease

Federico Di Tullio, Sue Bin Yang, Lida Yang, Bruno Cogliati, Shamsa Roshan, Kaiyuan Guo, Abigail Glezer, Joseph Conrad, Siddarth Vinod Kumar, Joana Almeida, Haoyuan Li, Shahina Saeed, Marina Bárcena‐Varela, Emily R. Bramel, Anthony Lozano, , Tianliang Sun

This study shows that deleting ZNRF3 and RNF43 in hepatocytes after MASH onset restores liver regeneration and reverses steatosis, inflammation, and fibrosis without causing tumorigenesis or hepatotoxicity.

bioRxiv · Jun 19, 2025 · PreprintCell Biology

Extracellular Vesicle-Associated Neutrophil Elastase Activates Hepatic Stellate Cells and Promotes Liver Fibrogenesis via ERK1/2 Pathway

Regina A. Oshins, Zachary Greenberg, Yunling Tai, Derrick Zhao, Xuan Wang, Borna Mehrad, Mei He, Ishan J. Patel, Laith Khartabil, Huiping Zhou, Mark Brantly, Nazli Khodayari

bioRxiv · Aug 20, 2024 · PreprintCell Biology