Striatal Mu-Opioid Receptor Activation Triggers Direct-Pathway GABAergic Plasticity to Induce Negative Affect
Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alex Stefanov, Ruifeng Chen, Emily J. Yu, Michelle A. Hook, Yun Yan Huang, Emmanuel Darcq, Jun Wang
This study shows that chronic opioid use induces GABAergic plasticity in striatal neurons, leading to hypodopaminergic states and negative affect, which contribute to relapse.
bioRxiv · May 23, 2022 · PreprintNeuroscience