Author

Ruifeng Chen

Texas A&M Health Science Center

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Biology Disciplines

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Neuroscience· 4

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Jun WangiD· 4 shared Himanshu GangaliD· 3 shared Xueyi XieiD· 3 shared Valerie VierkantiD· 2 shared William PurvinesiD· 2 shared Xuehua Wang· 2 shared Xuehua WangiD· 2 shared Zhenbo HuangiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

Jun WangORCID

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4 papers

Recent·Most cited

Extended Amygdala CRF Projections to Striatal Striosomes Potentiate Dopamine Suppression During Fentanyl Withdrawal

Xueyi Xie, Amanda Essoh, Ruifeng Chen, Xuehua Wang, Jun Wang

This paper identifies a CRF pathway in the extended amygdala that enhances striosomal suppression of dopamine during fentanyl withdrawal.

bioRxiv · Jun 26, 2026 · PreprintNeuroscience

Dual Engram Architecture within a Single Striatal Cell Type Distinctly Controls Alcohol Relapse and Extinction

Xuan Xie, Yufei Huang, Ruifeng Chen, Zhenbo Huang, Himanshu Gangal, Ziyi Li, Jiayi Lu, Adelis M. Cruz, Anita Chaiprasert, Emily Yu, Nicholas Hernandez, Valerie Vierkant, Runmin Wang, Xuehua Wang, R MAINS SMITH, Jun Wang

The paper identifies two distinct engram ensembles within striatal medium spiny neurons that encode opposing memories for alcohol relapse and extinction.

Neuron · Apr 14, 2026Peer-reviewedNeuroscience

Traumatic Brain Injury Exacerbates Alcohol Consumption and Neuroinflammation with Decline in Cognition and Cholinergic Activity

Himanshu Gangal, Jaclyn Iannucci, Yufei Huang, Ruifeng Chen, William Purvines, W. Taylor Davis, Arian Rivera, Giles Johnson, Xueyi Xie, Sanjib Mukherjee, Valerie Vierkant, Kaley Mims, Katherine O’Neill, Xuehua Wang, Lee A. Shapiro, Jun Wang

This study shows that traumatic brain injury increases alcohol consumption and impairs cognition by reducing cholinergic activity and increasing microglial cells in mice.

Translational Psychiatry · Oct 16, 2025Peer-reviewedNeuroscience

Striatal Mu-Opioid Receptor Activation Triggers Direct-Pathway GABAergic Plasticity to Induce Negative Affect

Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alex Stefanov, Ruifeng Chen, Emily J. Yu, Michelle A. Hook, Yun Yan Huang, Emmanuel Darcq, Jun Wang

This study shows that chronic opioid use induces GABAergic plasticity in striatal neurons, leading to hypodopaminergic states and negative affect, which contribute to relapse.

bioRxiv · May 23, 2022 · PreprintNeuroscience