Author

Emmanuel Darcq

InsermORCID 0000-0002-8377-8015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brigitte Lina KiefferiD· 2 shared Alba Caparros-RoissardiD· 1 shared Alex StefanoviD· 1 shared Anaïs F. BardetiD· 1 shared Anne‐Laurence BoutillieriD· 1 shared Ayikoe Guy Mensah‐NyaganiD· 1 shared Camille FalconnieriD· 1 shared Charles DecraeneiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Brigitte Lina KiefferORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IFNγ-associated immune--metabolic remodeling drives serotonin-kynurenine imbalance with cortical vulnerability in lupus-prone mice

Karim Matmat, Rosa‐Maria Guéant‐Rodriguez, Emmanuel Darcq, Okan Baspinar, Jean‐Marc Alberto, Jean‐Louis Guéant, Ayikoe Guy Mensah‐Nyagan, Hélène Jeltsch‐David

This study identifies IFNγ-driven immune-metabolic changes in lupus-prone mice that lead to serotonin-kynurenine imbalance and cortical vulnerability.

bioRxiv · Nov 19, 2025 · PreprintImmunology

Sex-divergent brain epigenetic reprogramming by chronic opioids

Camille Falconnier, Alba Caparros-Roissard, Hanuš Slavík, Mithil Gaikwad, Victor Mathis, Margot Diringer, Charles Decraene, Salim Megat, Sebahat Ozkan, Mohamad Yassine, Yahia Hadj-Arab, Pierre Hener, Robin Waegaert, Brigitte Lina Kieffer, Emmanuel Darcq, , Pierre-Éric Lutz

This study identifies sex-specific epigenetic changes in the nucleus accumbens of male and female mice exposed to chronic morphine, revealing shared biological dysregulation and potential therapeutic targets.

bioRxiv · Oct 27, 2025 · PreprintNeuroscience

Striatal Mu-Opioid Receptor Activation Triggers Direct-Pathway GABAergic Plasticity to Induce Negative Affect

Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alex Stefanov, Ruifeng Chen, Emily J. Yu, Michelle A. Hook, Yun Yan Huang, Emmanuel Darcq, Jun Wang

This study shows that chronic opioid use induces GABAergic plasticity in striatal neurons, leading to hypodopaminergic states and negative affect, which contribute to relapse.

bioRxiv · May 23, 2022 · PreprintNeuroscience

Neurons expressing mu opioid receptors of the habenula promote negative affect in a projection-specific manner

Julie Bailly, Florence Allain, Chloé Tirel, Florence Petit, Emmanuel Darcq, Brigitte Lina Kieffer

The paper shows that MHb-MOR neurons promote negative affect through distinct projection pathways to the IPN and DRN, revealing two routes for aversion and anxiety.

bioRxiv · Sep 13, 2021 · PreprintNeuroscience