Cardiac REDD1 alters glucose and fatty acid metabolic gene expression via an mTORC1-independent, PPAR alpha-dependent mechanism and drives hypertrophic growth
Mason Wheeler, Jamie Renick, Roslyn Fawbush, Emily McAlpin, Shaunaci A. Stevens, Karthi Sreedevi, Junco S. Warren, Michael Don Dennis, Jessica M. Pfleger
This study shows REDD1 promotes cardiac hypertrophy by enhancing glucose oxidation and suppressing fatty acid oxidation through PPAR alpha, independent of mTORC1 inhibition.
bioRxiv · Mar 18, 2026 · PreprintCell Biology