Author

Mason Wheeler

Virginia TechORCID 0000-0001-5166-9183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

Jessica M. PflegeriD· 3 shared Emily McAlpin· 1 shared Hanaa AbdelazimiD· 1 shared Jamie Renick· 1 shared John C. ChappelliD· 1 shared Junco S. WarreniD· 1 shared Karthi SreedeviiD· 1 shared Lucy L. Turner· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

Jessica M. PflegerORCID

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3 papers

Recent·Most cited

Elevating levels of neuronal MCU in the hippocampus enhances mitochondrial calcium uptake and respiratory efficiency proportional to demand

Mikel L. Cawley, Ryan N. Montalvo, Mason Wheeler, Lucy L. Turner, Jessica M. Pfleger, Zhen Yan, Shannon Farris

This study shows that increasing neuronal MCU in the hippocampus improves mitochondrial calcium uptake and respiratory efficiency in response to energy demand.

bioRxiv · Apr 16, 2026 · PreprintNeuroscience

Cardiac REDD1 alters glucose and fatty acid metabolic gene expression via an mTORC1-independent, PPAR alpha-dependent mechanism and drives hypertrophic growth

Mason Wheeler, Jamie Renick, Roslyn Fawbush, Emily McAlpin, Shaunaci A. Stevens, Karthi Sreedevi, Junco S. Warren, Michael Don Dennis, Jessica M. Pfleger

This study shows REDD1 promotes cardiac hypertrophy by enhancing glucose oxidation and suppressing fatty acid oxidation through PPAR alpha, independent of mTORC1 inhibition.

bioRxiv · Mar 18, 2026 · PreprintCell Biology

Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation

Hanaa Abdelazim, Mayd M. Alsalman, Mason Wheeler, Jessica M. Pfleger, John C. Chappell

This study investigates how murine cerebral capillary endothelial and pericyte cells respond to blood flow cessation, finding that pericytes mediate microvascular constriction via ET-1 and alter endothelial tight junctions.

bioRxiv · May 7, 2025 · PreprintCell Biology