Jessica M. Pfleger

Elevating levels of neuronal MCU in the hippocampus enhances mitochondrial calcium uptake and respiratory efficiency proportional to demand

This study shows that increasing neuronal MCU in the hippocampus improves mitochondrial calcium uptake and respiratory efficiency in response to energy demand.

Cardiac REDD1 alters glucose and fatty acid metabolic gene expression via an mTORC1-independent, PPAR alpha-dependent mechanism and drives hypertrophic growth

This study shows REDD1 promotes cardiac hypertrophy by enhancing glucose oxidation and suppressing fatty acid oxidation through PPAR alpha, independent of mTORC1 inhibition.

Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation

This study investigates how murine cerebral capillary endothelial and pericyte cells respond to blood flow cessation, finding that pericytes mediate microvascular constriction via ET-1 and alter endothelial tight junctions.

H2A.Z-dependent and -independent recruitment of metabolic enzymes to chromatin required for histone modifications

The paper identifies H2A.Z-dependent and -independent recruitment of metabolic enzymes to chromatin and shows their role in histone modifications in mouse heart cells.