Junco S. Warren

This study shows REDD1 promotes cardiac hypertrophy by enhancing glucose oxidation and suppressing fatty acid oxidation through PPAR alpha, independent of mTORC1 inhibition.

This study investigates whether PERM1 regulates systolic cardiac function by conducting a large-scale echocardiography analysis with increased sample size, finding significant differences in cardiac parameters between Perm1-KO and WT mice.

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

AAV9-PERM1 gene therapy preserves cardiac function in a mouse model of pressure overload-induced heart failure by maintaining mitochondrial biogenesis, respiration, and contractility.