Author

Karthi Sreedevi

Virginia TechORCID 0000-0002-8239-3025Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Junco S. WarreniD· 3 shared Alexey V. ZaitseviD· 2 shared Abigail Oforiwaa DokuiD· 1 shared Audrey Korte· 1 shared Brianna Goode· 1 shared Emily McAlpin· 1 shared Jamie Renick· 1 shared Jessica M. PflegeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPhysiology

Junco S. WarrenORCID

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3 papers

Recent·Most cited

Cardiac REDD1 alters glucose and fatty acid metabolic gene expression via an mTORC1-independent, PPAR alpha-dependent mechanism and drives hypertrophic growth

Mason Wheeler, Jamie Renick, Roslyn Fawbush, Emily McAlpin, Shaunaci A. Stevens, Karthi Sreedevi, Junco S. Warren, Michael Don Dennis, Jessica M. Pfleger

This study shows REDD1 promotes cardiac hypertrophy by enhancing glucose oxidation and suppressing fatty acid oxidation through PPAR alpha, independent of mTORC1 inhibition.

bioRxiv · Mar 18, 2026 · PreprintCell Biology

Does PERM1 Regulate Systolic Cardiac Function? A Game of Numbers.

Alexey V. Zaitsev, Karthi Sreedevi, Brianna Goode, Junco S. Warren

This study investigates whether PERM1 regulates systolic cardiac function by conducting a large-scale echocardiography analysis with increased sample size, finding significant differences in cardiac parameters between Perm1-KO and WT mice.

Scientific Reports · Feb 7, 2026Peer-reviewedPhysiology

PERM1 Gene Delivery via AAV Prevents Heart Failure in a Mouse Model of Pressure Overload

Karthi Sreedevi, Ryan N. Montalvo, Abigail Oforiwaa Doku, Audrey Korte, Rebekah Thomas, Sarah Salama, Steven Burrows, Zhen Yan, Alexey V. Zaitsev, Junco S. Warren

AAV9-PERM1 gene therapy preserves cardiac function in a mouse model of pressure overload-induced heart failure by maintaining mitochondrial biogenesis, respiration, and contractility.

bioRxiv · Sep 29, 2025 · PreprintPhysiology