Prostate-specific EV capture with sufficient RNA yield to enable transcriptomic profiling
Yang Yang, Julia Doo, Devin Perez, Kurt Franzen, Sinead Nguyen, Jasmyn Mirabal, Emily Mitsock, Sanoj Punnen, Sandra Marlene Gaston, Timothy Gerard, Alan S Pollack, Elena M. Cortizas, Sudipto K. Chakrabortty, Johan Skog, Joseph M. Johnson
The paper develops a method to specifically capture prostate-derived extracellular vesicles from urine, enabling transcriptomic analysis and improving specificity for prostate cancer detection.
bioRxiv · Sep 8, 2025 · PreprintCancer Biology